Expected results:

1. InterAct will produce evidence of the association of genetic variants with risk of type 2 diabetes and will investigate interaction between these genes.

2. InterAct will provide evidence of the association between dietary patterns and specific foods and nutrients with risk of diabetes.

3. The project will describe the association of physical activity with incident diabetes and will investigate the combined effects of activity and nutritional and dietary factors.

4. InterAct will demonstrate how the effect of genetic variants on diabetes risk is modified by lifestyle behavioural factors.

5. InterAct will show how these genetic variants modify response to lifestyle interventions.