General summary



The value of InterAct is likely to come not from a single report but rather from the production of a body of work outlining with confidence how genetic and lifestyle factors work together to lead to diabetes.


  • InterAct will produce evidence of the association of genetic variants with risk of type 2 diabetes and will investigate interaction between these genes.
  • InterAct will provide evidence of the association between dietary patterns and specific foods and nutrients with risk of diabetes.
  • The project will describe the association of physical activity with incident diabetes and will investigate the combined effects of activity and nutritional and dietary factors.
  • InterAct will demonstrate how the effect of genetic variants on diabetes risk is modified by lifestyle behavioural factors.
  • InterAct will show how these genetic variants modify response to lifestyle interventions.