RL1 Analysis of gene-lifestyle interaction in observational studies of diabetes incidence

The overall goal of this Research Line was to construct a nested case-cohort study for T2D within the EPIC observational cohort and to use this study as the basis for studying gene-lifestyle interaction.

• Follow up has been completed for an average of 8 years, which provided 4 million ‘person years’.  During this time 12,403 verified incident cases of type 2 diabetes were identified.
• A subcohort of 16,154 controls free of diabetes at baseline has also been identified.
• DNA extraction and genotyping has been undertaken using centralised high throughput methods.
• A central database for baseline, genetic and biomarker information has been created.
• A bespoke on line password protected ‘extranet’ website has been created to co-ordinate the activities for analysis in the InterAct project.