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Research line 1

RL1 Analysis of gene-lifestyle interaction in observational studies of diabetes incidence

IARCThe overall goal of this Research Line was to construct a nested case-cohort study for T2D within the EPIC observational cohort and to use this study as the basis for studying gene-lifestyle interaction.


  • Follow up has been completed for an average of 8 years, which provided 4 million ‘person years’.  During this time 12,403 verified incident cases of type 2 diabetes were identified.
  • A subcohort of 16,154 controls free of diabetes at baseline has also been identified.
  • DNA extraction and genotyping has been undertaken using centralised high throughput methods.
  • A central database for baseline, genetic and biomarker information has been created.
  • A bespoke on line password protected ‘extranet’ website has been created to co-ordinate the activities for analysis in the InterAct project.