RL1 Analysis of gene-lifestyle interaction in observational studies of diabetes incidence

The overall goal of this Research Line is to construct a nested case-control study for T2D within the EPIC observational cohort and to use this study as the basis for studying gene-lifestyle interaction.

Research Line specific objectives

• To ascertain potential cases of type diabetes described within the existing EPIC databases in order to establish a provisional ‘case' group.
• To verify the diagnosis of incident T2D in all potential cases.
• To identify a strategy for control selection and to implement this strategy by selecting suitable control individuals and providing details to allow sample retrieval.
• To retrieve plasma, serum and buffy coat samples from the EPIC central store for identified cases and controls.
• To establish a central database for all the information collected as part of this project.
• To co-ordinate the activities for designing the analysis of data collected in the InterAct project for the main effects analysis for genetics, diet, nutrition and physical activity, and interaction.