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Research line 2

RL2 Analysis of nutritional factors and physical activity in observational studies of diabetes incidence


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The overall goal of this Research Line was to study the association of nutritional, dietary and physical activity behaviours with incident diabetes in the nested case-cohort study and to contribute to the analysis of gene-lifestyle interaction. 

 

  • To provide information from self-report questionnaires on the estimated intake of specified nutrients in the individuals selected for the nested case-cohort study and to co-ordinate the analysis of the association of self-reported nutrient intake with incident diabetes.




  • To characterise the food and overall dietary pattern of participants in the nested case-cohort study and to describe the association between these factors and incident diabetes.
  • To co-ordinate the analysis of the association of nutritional biomarkers and incident diabetes.
  • To analyse the role of intermediate pathways in explaining the interaction between lifestyle behaviours and genetic factors on the incidence of diabetes. 
  • To utilise discovery approaches to investigating potential pathways using methods that are not dependent upon prior knowledge such as metabolomics. 
  • The EPIC physical activity questionnaire has been validated within InterAct allowing further study of the association of activity with incident diabetes.

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