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Research line 3

RL3 Analysis of genetic factors in observational studies of diabetes incidence


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The overall goal of this Research Line was to study the association of genetic variation with incident diabetes in the nested case-cohort study and to contribute to the analysis of main genetic effects and gene-lifestyle interaction.

 

  • To identify biologically plausible genes that may interact with lifestyle behaviours on the incidence of diabetes and to identify lists of single nucleotide polymorphisms (SNPs) in the selected genes.
  • To identify an efficient and economic organisation to undertake the DNA extraction for the nested case-cohort study to pre-set quality criteria.

  • To oversee the processes of DNA extraction, quantification and arraying and to ensure quality control.
  • To undertake the genotyping of the single nucleotide polymorphisms and to deliver complete and accurate data to the central datahub.
  • To prepare an analytical strategy for the analysis of the main genetic associations of the genes and SNPs in collaboration with the main analytical centre.

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